Books

NMR-Spectroscopy in Drug Development and Analysis

tl_files/spectralservice_design/images/Content Bilder/book_nmrdrug_cover.jpgHardcover, 312 Pges
1999 at Wiley-VCH Verlag
ISBN: 978-3-527-30092-1

"Since the development of the NMR spectrometer in the 1950s, NMR spectra have been widely used for the elucidation of the 2D structure of newly synthesizde an natural compounds. In the 1980s, high resolution NMR spectrometer (>300 MHz) and 2D experiments were introduced, which opens up the possibility to determine the 3D structure of large molecules, especially biomolecules. However, NMR spectroscopy has been rarely applied to drug analysis."
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NMR-Spectroscopy in Pharmaceutical Analysis

tl_files/spectralservice_design/images/Content Bilder/book_nmrpharma_cover.jpgHardcover, 528 pages
2008 at Elsevier
ISBN-10: 0-444-53173-4


"For almost a decade, quantitative NMR spectroscopy (qNMR) has been established as valuable tool in drug analysis. In all disciplines, i. e. drug identification, impurity profiling and assay, qNMR can be utilized. Separation techniques such as high performance liquid chromatography, gas chromatography, super fluid chromatography and capillary electrophoresis techniques, govern the purity evaluation of drugs. However, these techniques are not always able to solve the analytical problems often resulting in insufficient methods. Nevertheless such methods find their way into international pharmacopoeias. Thus, the aim of the book is to describe the possibilities of qNMR in pharmaceutical analysis. Beside the introduction to the physical fundamentals and techniques the principles of the application in drug analysis are described: quality evaluation of drugs, polymer characterization, natural products and corresponding reference compounds, metabolism, and solid phase NMR spectroscopy for the characterization drug substances, e.g. the water content, polymorphism, and drug formulations, e.g. tablets, powders. This part is accompanied by more special chapters dealing with representative examples. They give more detailed information by means of concrete examples."
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Publications

31P-NMR Validation of Phosphatidyl-Serine (EN) 31P-NMR Validation of Phosphatidyl-Serine (EN) 1,842.4 kB

Final Study Report - Validation of 31P-NMR Quantification Method of Phosphatidyl-Serine (PS)

NMR-Spectroscopy of Bio-Diesel (EN) NMR-Spectroscopy of Bio-Diesel (EN) 127.9 kB

Analysis of Bio-Diesel and Gasoline in Diesel Fuelö by NMR Spectroscopy
A quick and robust alternative to gas chromatography!

Quantitative NMR mit Cryo Probe (DE) Quantitative NMR mit Cryo Probe (DE) 332.9 kB

Quantitative NMR - Innovatives Verfahren in der Analytik von Arzneistoffen

The pathway of Omega-3 fatty acids in hen's eggs (EN) The pathway of Omega-3 fatty acids in hen's eggs (EN) 194.7 kB

13C-NMR-spectroscopy is shown to be an excellent tool for and yzing the fatty acid composition of different lipids. The NMR-spectra of egg yolk lecithin and egg slot DRA-enriched eggs as well as the spen al diet (single cells) are compared to obtain the differences in the relative amount and the distribution of ω3 fatty acids in sn-1/3 and sn-2 position of the glyceride backbone. 13C-NMR-spectroscopy allows the guantitation of the total content of ω-3, ω-6, ω-7, ω-9 and saturated fatty acids in a very short time and without chemical treatment of the sample.

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Quantitative NMR with Cryo Probe (EN) Quantitative NMR with Cryo Probe (EN) 1,019.8 kB

Presentation for the 100th AOCS annual Meeting - Quantitative 31P-NMR with CQNP at 600 MHz

PVC/AOX-Projekt Herrieden (DE) PVC/AOX-Projekt Herrieden (DE) 308.0 kB

Hohe AOX durch PVC: Eine Methode zur Verursacherermittlung und Konzeopte für emissionsverhindernde Maßnahmen.
Bestimmung von PVC als Komponente aus dem Summenparameter AOX mittels NMR-Spektroskopie.
Gefördert durch die Deutsche Bundesstiftung Umwelt.

13C-NMR-spectroscopy is shown to be an excellent tool for and yzing the fatty acid composition of different lipids. The NMR-spectra of egg yolk lecithin and egg slot DRA-enriched eggs as well as the spen al diet (single cells) are compared to obtain the differences in the relative amount and the distribution of ω3 fatty acids in sn-1/3 and sn-2 position of the glyceride backbone. 13C-NMR-spectroscopy allows the guantitation of the total content of ω-3, ω-6, ω-7, ω-9 and saturated fatty acids in a very short time and without chemical treatment of the sample.